Difference between revisions of "Cogan's lid twitch and eyelid hopping"

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1. Campbell WW. Clinical signs in neurology : a compendium. Philadelphia: Wolters Kluwer Health, 2016.
 
1. Campbell WW. Clinical signs in neurology : a compendium. Philadelphia: Wolters Kluwer Health, 2016.
 +
 
2. Campbell WW. DeJong's the neurologic examination, 7th ed. Philadelphia: Wolters Kluwer
 
2. Campbell WW. DeJong's the neurologic examination, 7th ed. Philadelphia: Wolters Kluwer
 
Health/Lippincott Williams & Wilkins, 2013.
 
Health/Lippincott Williams & Wilkins, 2013.
 +
 
3. Cogan DG. Myasthenia gravis: a review of the disease and a description of lid  
 
3. Cogan DG. Myasthenia gravis: a review of the disease and a description of lid  
 
twitch as a characteristic sign. Arch Ophthalmol. 1965 Aug;74:217-21.
 
twitch as a characteristic sign. Arch Ophthalmol. 1965 Aug;74:217-21.
 +
 
4. Singman EL, Matta NS, Silbert DI. Use of the Cogan lid twitch to identify
 
4. Singman EL, Matta NS, Silbert DI. Use of the Cogan lid twitch to identify
 
myasthenia gravis. J Neuroophthalmol. 2011 Sep;31(3):239-40.  
 
myasthenia gravis. J Neuroophthalmol. 2011 Sep;31(3):239-40.  
  
 
[[Category:Cranial Nerve Signs]]
 
[[Category:Cranial Nerve Signs]]

Latest revision as of 19:27, 26 January 2018

Cogan's lid twitch sign, characteristic of myasthenia gravis, consists of a brief overshoot twitch of lid retraction following sudden return of the eyes to primary position after a period of downgaze.(1-3) The lid will briefly twitch upwards then settle back to its previous position. (Video) This sign should increase suspicion of MG but is not diagnostic; it may be seen in other conditions. A similar upward twitch may occur on glancing quickly to the side from primary position (eyelid hopping).

In a series of 117 patients, the specificity of the lid twitch sign was 99%, the sensitivity was 75% and the false-positive rate was 1%.(4)

References

1. Campbell WW. Clinical signs in neurology : a compendium. Philadelphia: Wolters Kluwer Health, 2016.

2. Campbell WW. DeJong's the neurologic examination, 7th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2013.

3. Cogan DG. Myasthenia gravis: a review of the disease and a description of lid twitch as a characteristic sign. Arch Ophthalmol. 1965 Aug;74:217-21.

4. Singman EL, Matta NS, Silbert DI. Use of the Cogan lid twitch to identify myasthenia gravis. J Neuroophthalmol. 2011 Sep;31(3):239-40.